Interference within cancer cells.

The CASCADEplus system and its intracellular activities.

Cancer cells are most often regular human cells with a difference: a altnernation in or a kind of serious malfunctioning inside the particular cell's DNA and its derivative process of coding for specific proteins.

Seen from that perspective: there's a logic rationale, to presume that direct and or indirectly influencing the process of (mis)coding for proteins, due to an alternation in the particular DNA of the (cancer)cell, can or may lead to a successful therapeutic intervention. That presumption is actually rather factual in therapies against specific cancer.

There's already broad range of approved anticancer drugs that have its therapeutic effects inside cancer cells. For example the group of so called topoisomerase-inhibitors like irinotecan and topothecan. Both approved drugs are derivates of campothecin, which is a substance derived from a tree called: campotheca acuminata.

Another subgroup in the area of drugs that work within cancer cells, is the group of so called B-RAF-kinase inibitors. These drugs interfere with the so called B-RAF protein. The B-RAF protein is sending signals inside cells and is involved in directing cell growth.

Drugs that treat specific cancers that are driven by B-RAF mutations, have been developed. For example vemurafenib and dabrafenib, are approved by FDA for treatment of late-stage skin cancer or melanoma. 

The plant-derived Taxol/Paclitaxel anticancer drug, aims to interfere with the intracellular process of cell dividing or mitosis.

The groups of topoisomerase-inhibitors, B-RAF kinase inhibitors and mitosis blockers are not seen as the silver bullets in cancer treatments. These drugs are often used, as adjuvants, in combination with other types of anticancer drugs.

In the CASCADEplus system there's a focus on, so called, translational interference. Which means that the system seeks to disturb key-signals within cancer cells. This disturbance can be aimed at 'killing' the cell, to manipulatethere ligands on cancer cell curfaces or just to infere in key functions of the particular cancer cells. No silver bullets either, but within the system, various of such such are being fired at a broad range of intra-cellular targets.