Akkermansia Muciniphila is a bacteria. It has an inversely proportional relation with immune-checkpoint-blockers in cancer therapies. This Akkermansia bacteria seems to rescue exhausted CD8+ lymphocytes. 

It is advised to take capsulated Akkermansia Muciniphila once daily.

Alantolactone is a plant derived substance. Studies revealed that it can affect intracelluar mechanisms, within cancer cells, that are directly related to metastasis  of certain cancer cells.

Alantolactone can be derived from the root of the plant inula helenium.

The substance is available in capsules.

Daily recommended dosage: 1000 mg.

Apigenin can be found in many plants. It is a natural product belonging to the flavone class of substances.

Apigenin works intracellular and triggers apoptosis, inhibits proliferation and stimulates immune responses in and vs. cancers. 

It is strongly advised to use the apigenin that is enclosed in a lipid formula. 

The lipid formulation ensures a better bioavailability. 

Daily recommended dosage: 400 mg.

Astragalus membranaceus  is a member of the fabaceae group of plants. In China, this pant has been in use for 1000's of years. 

Astragalus membranaceus has specific immuno stimulating and anti-cancer properties. AM has been found to be capable of shrinking or stabilizing tumors by direct anti-proliferation and pro-apoptosis effect on tumor cells. 

Further, Astragalus membranaceus  also ameliorates immunosuppression by activating M1 macrophages and the T-cells tumor-kill function, in so called tumor microenvironments.

Recommended daily dosage: 1000 mg.

 Camu Camu  or Myrciaria dubia, is a small bushy riverside tree from the Amazon rainforest in Peru and Brazil, which grows to a height of 3–5 metres. 

Camu Camu contains castalagin, a so called polyphenol, which increases the effectiveness of immunotherapy - vs. immune-checkpoints - by altering the microbiome.

Daily recommended dosage: 1000 mg per day.

Chaga or Inonotus obliquus is a fungus in the family hymenochaetaceae. It is parasitic on birch trees. The sterile conk is irregularly formed and resembles a tar a-like, burnt charcoal.

The extracts of Chaga demonstrate potent anti-tumor activities and have been used to treat cancer in several countries. It enhances the effects of some chemotherapeutics. 

Chaga causes upregulation of Bax and caspase-3 and downregulation of Bcl-2, leading to apoptosis of cancer cells. ColoreInotodiol, a substance isolated from chaga, inhibited proliferation of cancer cells and induced apoptosis.

Chaga's powerful anti-cancer substances can easily be extracted by water. 

Daily recommended dosage: 1000 mg.

Clostridium butyricum is a butyrate-producing human gut bacteria that has been safely used as a probiotic for decades.

Clostridium butyricum has anti-cancer properties as it is able to produce butyrate and butyrate can inhibit the proliferation of tumor cells and enhance efficiacy of immunotherapy. 

Daily recommended dosage: 1 capsule  a day of clostridum butyricum bacteria.

Ellagic acid  is a so called polyphenol found in numerous fruits and vegetables. Pomegranate has a high grade of ellagic acid.

Ellagic acid has anti-cancer properties as it inhibits carcinogen-induced adduct formation, blocks keys signalling  in various cancers. 

Daily recommended dosage: 1000 mg.

Fisetin is a so called flavonoid. It is found in many fruits and vegetables, such as strawberries, apples, persimmons, onions, and cucumbers.

Fisetin exhibits several beneficial effects in cancer cells, including the suppressing proliferation, inducing apoptosis, reducing of angiogenesis, preventing oxidative stress, inhibiting migration, and enhancing chemotherapeutic effects. 

Daily recommended dosage: 100/200 mg.

Gynostemma  pentaphyllum also called jiaogulan in China, is a dioecious, herbaceous climbing vine of the family cucurbitaceae (cucumber or gourd family), widely distributed in South and East Asia as well as New Guinea.

Gynostemma  pentaphyllum  induces apoptosis by inhibiting the so called PI3K/AKT/mTOR intracellular pathway and enhances T-cell antitumor immunity by inhibiting PD-L1 on cancer cells.

Daily recommended dosage: 500 mg.

Matrine is an alkaloid found in plants from the family fabaceae. It has a variety of pharmacological effects, including anti-cancer effects.

Matrine significantly inhibited cancer cell growth by inducing apoptosis. It als so induced ferroptosis in cancer cells and suppressed metastasis of a variety of cancer cells. 

Please note: do not buy the purified matrine! 

Instead: buy the capsulated whole herb. 

1000 mg of the purified matrine is toxic!

Matrine is also sold as Ku Shen, made from  the Sophora Flavescens root. Capsulated Ku Shen is better available.

Recommended daily dosage: the whole herb, 1000 mg.

Oenothera biennis  the common evening-primrose, is a species of flowering plant in the family Onagraceae, native to eastern and central North America and widely naturalized elsewhere in temperate and subtropical regions.

Oenothera biennis  has anti-cancer effects, by induction of apoptosis, inhibiting angiogenesis, halting cell proliferation and has immunostimulating effects by blocking PD-1/PD-L1.

Daily recommended dosage: 1000 mg.

Physalis Peruviana is a plant belonging to the nightshade family (solanaceae) native to Chile and Peru. In English, its common names include Cape gooseberry, goldenberry and Peruvian groundcherry. 

Physalis Peruviana has been used over hundreds of years in traditional medicine. 

Physalis Peruviana contains two powerful anti-cancer molecules. 

1.  Physapruin A, this substance  modulates the oxidative-stress response, cell-cycle disturbance, apoptosis.

2. Whitaferin A, this substance leads to inhibition of cancer cell proliferation and cell cycle arrest, ultimately leading to apoptosis or cell death. Withaferin A is also able to reverse chemoresistance in certain cancers.

Daily recommended dosage: Physalis Peruviana is available in a dried fruit variety. Eat max. 100 grams per day. 

Quercetin is a plant flavonol from the flavonoid group of polyphenols. It can be found in many fruits, vegetables, leaves, seeds.

Quercetin is able to decrease tumor growth through targeting VEGFR-2-mediated angiogenesis and suppresses metastasis in a broad range of malign cancers. It also inhibits the interaction between the immune-checkpoint PD-1 and its ligand PD-L1. 

Quercetin is furthermore able to inhibit the expression of the Yes-associated protein (YAP). YAP is a relatively new target in cancer research and newly developed YAP-blockers reveal promising data.

And as a cherry on the pie: quercetin is able to block the so callen YY1 protein. YY1 or Yin Yang 1 is a relatively new anti-cancer target. A very influential target within cancer cells.  

Via oral ingestion, quercetin is in its regular form, not leading to a good bioavailability. Therefore it is recommended to buy the liposomal formulation. 

Daily recommended dosage: 1000 mg. 

Raisins, besides being a healthy snack, they contain quercetin. A study revealed that when quercetin is incapsulated in raisins, the oral ingestion, leads to a higher bioavailability.

You don't like raisins?

Well, let the raisins soak for a few hours in a mixture of water and rum aroma and use those raisins for a great apple pie or a home made bread?

Daily recommended dosage: max 50 grams.

Rehmannia is a genus of seven species of flowering plants, belonging to the order Lamiales and family Orobanchaceae, which are endemic to China.

Rehmannia can induce the immune activation of B cells, T cells, Natural Killer cells and so called dendritic cells. This activation is enhancing anti-cancer effects of the aforementioned immune cells. 

Rehmannia capsules are also sold under the Chinese name of Sheng Di Huang.

Daily recommended dosage: 500 mg.

Rutin is a so called flavonoid glycoside and can be found in a wide variety of plants, including citrus.

Rutin acts as a small-molecule inhibitor to the so called CD155/TIGIT pathway, thus leading to a direct stimulation of otherwise dysfunctional NK-/T-cells vs. various types of cancer.

Recommended daily dosage: 500 mg.

Bacteria are very important factors in our total well being. In the gut microbiome, a direct interaction of our immune system and microbes is unmistakable.

Bacteria have a direct influence on our immune system and our immune system has a direct influence on various types of cancer. So you better be a good host to your gut microbiome.

Bacteria inside our gut microbiome do not prefer to consume diet coke, pizza's, salty sausages etc. Such a diet causes a disbalance in your gut microbiome. Your gut bacteria love fruits and vegetables. So 30 to 40% of your daily food intake shall be: fruits and (fresh)vegetables.  

Daily recommended bacteria: Akkermansia Muciniphila and a bacteria mix for the gut are benificial to your microbiome. There are a variety of brands, which offer capsulated bacteria, with up to 30 different strains in a single capsule.